By B.G. Firkin
The objective of this e-book is to introduce the scientific scholar, fresh clinical graduates occupied with postgraduate education and physicians in perform to the position of the platelet in body structure and disorder. it's not meant to be an encyclopaedic assessment of all of the literature during the last few many years, yet mostly represents a private account, and even supposing resultant prejudices take place, an test has been made to stress to the reader parts of doubt, and aspect tips on how to different assets which could discover those questions extra totally in chosen references on the finish of every bankruptcy. I recognize assistance from my secretaries, Ms Carolyn Harvey and Mrs Marjorie Brown with no whom the ebook may by no means were began, not to mention accomplished. a few illustrations and figures have been made by means of Mr W. Shepherd of Monash college and Ms A. Leaman of the Alfred clinic. i'm indebted to Mrs E. Hagon who learn and corrected a few of the chapters, and for the consistent support via dialogue and debate with my shut collaborators in study, Dr Margaret Howard and Dr Sharron pfueller. Dr Siew Choong, Mrs Maureen Broadway and Ms Ilona Lakatos documented the equipment utilized in our laboratory to check platelets as defined within the Appendix.
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Extra resources for The Platelet and its Disorders
Surface labelling as a tool to determine structure-function relationships of platelet plasma membrane glycoproteins. Thromb. , 42, 1638 POLLET, R. J. and LEVEY, G. S. (1980). Principles of membrane receptor physiology and their application to clinical medicine. Ann. Intern. Y. L. (1981). Thrombin-induced platelet membrane glycoprotein lIb and IlIa complex formation. An electron microscope study. J. Exp. , 154, 1058 REIMERS, H. , PACKHAM, M. , KINLOUGH-RATHBONE, R. L. F. (1973). Effect of repeated treatment of rabbit platelets with low concentrations of thrombin on their function, metabolism and survival.
One is a permeability factor which induces histamine release from mast cells, and another is a chemotactic factor which activates the fifth component of complement releasing a chemotactic factor for segmented neutrophils. A bactericidal factor has also been described and called (3-lysin, but other work has not revealed any antibacterial factor in platelets. Thrombospondin is a glycoprotein with a molecular weight of 450000, and is released from platelets after they are treated with thrombin. This protein contains three polypeptide chains and binds to heparin.
Thus PGH2 added to aspirin treated endothelial cells results in a production of prostacyclin. Similarly, it has been shown that stimulation of platelets by an ionophore which will bring about the release reaction with release of endoperoxides as well as thromboxane A2 results in aspirin treated endothelial cells producing prostacyclin. Thus the beneficial effects of aspirin in thrombotic situations may relate to the endothelial cells' capacity to resynthesize cyclo-oxygenase unlike the platelet, and that regardless, should platelet aggregation occur, the release of endoperoxides (PGH2) from the platelets would result in the endothelial cells producing POI2.