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Download Chemical biology of glycoproteins by Zhongping Tan, Lai-Xi Wang (eds.) PDF

By Zhongping Tan, Lai-Xi Wang (eds.)

Glycans play an important function in modulating protein constitution and serve as from involvement in protein folding, solubility and balance to law of tissue distribution, popularity specificity, and organic job. they could act as either confident and adverse regulators of protein functionality, supplying an extra point of regulate with appreciate to genetic and environmental conditions.Due to the complexity of Read more...

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This e-book describes the improvement and alertness of glycoprotein and glycan synthesis applied sciences as instruments for realizing and manipulating protein glycosylation. Read more...

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P. Wang, S. Dong, J. H. Shieh, E. Peguero, R. Hendrickson, M. A. Moore and S. J. Danishefsky, Science, 2013, 342, 1357–1360. M. A. Walczak, J. Hayashida and S. J. Danishefsky, J. Am. Chem. , 2013, 135, 4700–4703. C. Toonstra, M. N. Amin and L. X. Wang, J. Org. , 2016, 81, 6176–6185. P. E. Dawson, T. W. Muir, I. Clark-Lewis and S. B. Kent, Science, 1994, 266, 776–779. Q. Wan and S. J. Danishefsky, Angew. , Int. Ed. , 2007, 46, 9248–9252. X. Guan, P. K. Chaffey, C. Zeng and Z. Tan, Top.

35,36 The inhibition of the early steps in glycan processing may affect the appropriate folding and/or secretion of the viral envelope glycoproteins. 37 It should be pointed out that the success of this approach will rely on the difference in the N-glycan structure and function between cancer cells and normal cells, as well as the expression levels of those glycanprocessing enzymes in cancer vs. normal cells. 3). 3 Dual  inhibitory effect of fluorinated monosaccharide analogs on glycosyltransferases in mammalian cells to perturb fucosylation and sialylation of N-glycoproteins.

P. Wang, S. Dong, J. H. Shieh, E. Peguero, R. Hendrickson, M. A. Moore and S. J. Danishefsky, Science, 2013, 342, 1357–1360. M. A. Walczak, J. Hayashida and S. J. Danishefsky, J. Am. Chem. , 2013, 135, 4700–4703. C. Toonstra, M. N. Amin and L. X. Wang, J. Org. , 2016, 81, 6176–6185. P. E. Dawson, T. W. Muir, I. Clark-Lewis and S. B. Kent, Science, 1994, 266, 776–779. Q. Wan and S. J. Danishefsky, Angew. , Int. Ed. , 2007, 46, 9248–9252. X. Guan, P. K. Chaffey, C. Zeng and Z. Tan, Top.

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