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Download [Article] Robust modeling in screening studies estimation of by Shen Y. PDF

By Shen Y.

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Review articles have referred to two RCTs of oxcarbazepine in bipolar disorder, but full 48 49 publications were not found. • COCHRANE META-ANALYSIS (EPILEPSY) ♦ Oxcarbazepine Efficacy in the Meta-analysis. Odds ratio for 50% or greater reduction in seizure frequency in patients with partial seizures was significantly higher for oxcarbazepine compared to placebo. ♦ In add-on trials, oxcarbazepine was significantly more likely to be withdrawn due to side effects than placebo. 16 ♦ American Psychiatric Society ◊ For acute mania or mixed episodes, oxcarbazepine is considered an alternate treatment and is listed as the fourth choice.

Bowden CL, Calabrese JR, Sachs G, et al. A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently manic or hypomanic patients with bipolar I disorder. Arch Gen Psychiatry. 2003;60(4):392â 400. 22. Calabrese JR, Bowden CL, Sachs G, et al. A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently depressed patients with bipolar I disorder. J Clin Psychiatry. 2003;64(9):1013â 1024. 23. GlaxoSmithKline. Lamictal prescribing information, 2004.

25 mg twice daily ⋅ Usual Maintenance Dosage. 100 to 400 mg/day (titrate by 25 mg every 2 weeks) ◊ Adjunctive therapy for valproate (age 2 to 12 years) ⋅ Weeks 1 and 2. 15 mg/kg/day in one or two divided doses, rounded off to the nearest whole tablet 38 39 ⋅ Weeks 3 and 4. 3 mg/kg/day in one or two divided doses, rounded off to the nearest whole tablet ⋅ Usual Maintenance Dosage. 1 to 5 mg/kg/day (maximum 200 mg/day in one or two divided doses) ⋅ Increase doses every 1 to 2 weeks as follows. 3 mg/kg/day, round off this amount to the nearest whole tablet, and add this amount to the previously administered daily dose.

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