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Extra resources for [Article] Robust modeling in screening studies estimation of sensitivity and preclinical sojourn time distribution
Review articles have referred to two RCTs of oxcarbazepine in bipolar disorder, but full 48 49 publications were not found. • COCHRANE META-ANALYSIS (EPILEPSY) ♦ Oxcarbazepine Efficacy in the Meta-analysis. Odds ratio for 50% or greater reduction in seizure frequency in patients with partial seizures was significantly higher for oxcarbazepine compared to placebo. ♦ In add-on trials, oxcarbazepine was significantly more likely to be withdrawn due to side effects than placebo. 16 ♦ American Psychiatric Society ◊ For acute mania or mixed episodes, oxcarbazepine is considered an alternate treatment and is listed as the fourth choice.
Bowden CL, Calabrese JR, Sachs G, et al. A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently manic or hypomanic patients with bipolar I disorder. Arch Gen Psychiatry. 2003;60(4):392â 400. 22. Calabrese JR, Bowden CL, Sachs G, et al. A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently depressed patients with bipolar I disorder. J Clin Psychiatry. 2003;64(9):1013â 1024. 23. GlaxoSmithKline. Lamictal prescribing information, 2004.
25 mg twice daily ⋅ Usual Maintenance Dosage. 100 to 400 mg/day (titrate by 25 mg every 2 weeks) ◊ Adjunctive therapy for valproate (age 2 to 12 years) ⋅ Weeks 1 and 2. 15 mg/kg/day in one or two divided doses, rounded off to the nearest whole tablet 38 39 ⋅ Weeks 3 and 4. 3 mg/kg/day in one or two divided doses, rounded off to the nearest whole tablet ⋅ Usual Maintenance Dosage. 1 to 5 mg/kg/day (maximum 200 mg/day in one or two divided doses) ⋅ Increase doses every 1 to 2 weeks as follows. 3 mg/kg/day, round off this amount to the nearest whole tablet, and add this amount to the previously administered daily dose.