By Louis Sokoloff (auth.), B. W. Agranoff, M. H. Aprison (eds.)
This sequence has been directed at supplying scientists owning significant bio chemical historical past with really expert stories of neurobiological curiosity. a few have handled accomplished our bodies of study, whereas others encompass wide reviews of analysis in growth, judged to be of present curiosity to the lively researcher. we've got chosen well-known scientists and allowed them freedom to mirror and speculate within the box within which they've got completed promenade inence. We notice with disappointment the passing of Dr. 10rdi FoIch-Pi, who served as an advisory editor whilst the sequence used to be initiated. He performed a valuable position within the improvement of neurochemistry, in addition to the production societies and journals. he'll be remembered fondly by means of all these whose lives he touched. The editors recognize the cooperation of the Upjohn corporation within the education of the colour plate incorporated during this quantity. We additionally recognize the skillful editorial tips of Dr. Kenneth C. Leskawa. we're happy to honor the retirement of Dr. E. Martin Gal, a former advisory editor of Advances, with the inclusion of a bankruptcy through him during this volume.
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Extra resources for Advances in Neurochemistry
Is based on equations (40) and (42). These equations state that if the [14C]-DG is administered in such a way that its concentration in 22 CHAPTER I arterial plasma achieves and maintains a constant level for a sufficiently long time, the concentrations of free [14C]-DG and its rates of phosphorylation in the tissues will reach a steady state like that already existing for glucose. , ratio of [14C]-DG to glucose concentrations) in arterial blood and plasma, becomes equal to the lumped constant [equation (42)].
0 30 35 40 45 TIME (MIN) FIGURE 5. Influence of time and rate constant (k~ + kj) on integrated precursor pool specific activity. 693 j( k~ + kj). ) be seen that enormous errors of several hundred percent can be encountered with erroneous values of the rate constants early following the pulse, but the curves all rise and converge within a narrow range by 45 min, despite the wide span of rate constants used. It is obvious that there is then little difference in the final result, regardless of the rate constants used.
THEORETICAL AND PRACTICAL CONSIDERATIONS AND LIMITATIONS Equation (30), the operational equation of the method, defines the variables to be measured to determine local cerebral glucose utilization. , and the lumped constant, which are not determined uniquely in each animal at the time of the experiment but are evaluated in separate groups of animals of the same species under conditions often different from those of the experiment. There is no assurance, of course, that these constants are universal and apply to all individual animals of a species under all conditions.